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小松 紀子
Noriko Komatsu, Ph.D.

東京大学大学院医学系研究科 免疫学 准教授
E-mail address: koma-im[@]m.u-tokyo.ac.jp


原著論文、総説・著書(英文)

Ando Y, Tsukasaki M*, Huynh NC, Zang S, Yan M, Muro R, Nakamura K, Komagamine M, Komatsu N, Okamoto K, Nakano K, Okamura T, Yamaguchi A, Ishihara K, Takayanagi H*. (*Corresponding authors) The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. Int J Oral Sci. 16:18(2024) [PubMed].

Komagamine M, Komatsu N, Ling R, Okamoto K, Shi T, Matsuda K, Takeuchi T, Kaneko Y, and Takayanagi H. Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss. Inflammation and Regeneration. 43:44(2023) [PubMed].

Yan M, Tsukasaki M, Muro R, Ando Y, Nakamura K, Komatsu N, Nitta T, Okamura T, Okamoto K, Takayanagi H. Identification of an intronic enhancer regulating RANKL expression in osteocytic cells. Bone Res. 11:43(2023) [PubMed].

Yan M, Komatsu N, Muro R, Huynh NC, Tomofuji Y, Okada Y, Suzuki HI, Takaba H, Kitazawa R, Kitazawa S, Pluemsakunthai W, Mitsui Y, Satoh T, Okamura T, Nitta T, Im SH, Kim CJ, Kollias G, Tanaka S, Okamoto K, Tsukasaki M, Takayanagi H. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Nat Immunol. 9:1330-1341 (2022) [PubMed].

Tsukasaki M, Komatsu N, Negishi-Koga T, Huynh NC, Muro R, Ando Y, Seki Y, Terashima A, Pluemsakunthai W, Nitta T, Nakamura T, Nakashima T, Ohba S, Akiyama H, Okamoto K, Baron R, Takayanagi H. Periosteal stem cells control growth plate stem cells during postnatal skeletal growth. Nat Commun 13, 4166 (2022) [PubMed]

Komatsu N, Takayanagi H. Mechanisms of joint destruction in rheumatoid arthritis ー immune cell-fibroblast-bone interactions. Nat Rev Rheumatol.(2022) [Online Published]

Komatsu N, Win S, Yan M, Huynh N C-N, Sawa S, Tsukasaki M, Terashima A, Pluemsakunthai W, Kollias G, Nakashima T, Takayanagi H. Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. J Clin Invest. 10.1172/JCI143060.(2021) [PubMed]

Tsukasaki M, Huynh NC, Okamoto K, Muro R, Terashima A, Kurikawa Y, Komatsu N, Pluemsakunthai W, Nitta T, Abe T, Kiyonari H, Okamura T, Sakai M, Matsukawa T, Matsumoto M, Kobayashi Y, Penninger JM, Takayanagi H. Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab.2:1382–1390.(2020) [Online Published]

Tsukasaki M, Asano T, Muro R, Huynh N C-N, Komatsu N, Okamoto K, Nakano K, Okamura T, Nitta T, Takayanagi H. OPG Production Matters Where It Happened. Cell Reports.2:1382–1390.(2020) [Online Published]

Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, Isobe J, Yamada T, Muro K, Yanagisawa Y, Nakamura A, Fujimura Y, Saeki A, Ueda M, Matsumoto R, Asaoka H, Clarke J M, Harada Y, Umemoto E, Komatsu N, Okada T, Takayanagi H, Takeda K, Tomura M, Hase K. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine.58:102913.(2020) [Online Published]

Komatsu N, Takayanagi H. T Cells in The Regulation of Bone Metabolism. Encyclopedia of Bone Biology. vol[1] 12-19 Oxford: Academic Press (2020)

Komatsu N, Takayanagi H.
Immune-bone interplay in the structural damage in rheumatoid arthritis. Clin Exp Immunol. 194(1):1-8 (2018) [PubMed]

Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H.
Host defense against oral microbiota by bone-damaging T cells. Nat Commun.9:701(2018) [PubMed]

Tsukasaki M, Hamada K, Okamoto K Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H.
LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res. 32(3):434-439. (2017) [PubMed]

Guerrini MM, Okamoto K, Komatsu N, Sawa S, Danks L, Penninger JM, Nakashima T, Takayanagi H.
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43(6):1174-85 (2015) [PubMed]

Komatsu N, Takayanagi H.
Regulatory T cells in Arthritis.Prog Mol Biol Transl Sci.136:207-15 (2015) [PubMed]

Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, Kodama T, Takayanagi H.
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.Cell.163(4):975-87 (2015) [PubMed]

Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T, Takayanagi H.
RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.Ann Rheum Dis.75(6):1187-95. (2016) [PubMed]

Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
Immune complexes regulate bone metabolism through FcRγ signalling.Nat Commun.6:6637. (2015) [PubMed]

Komatsu N, Takayanagi H. Arthritogenic T cells in autoimmune arthritis. Int J Biochem Cell Biol. 58:92-6 (2015) [PubMed]

Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-Hora, M., Kodama, T., Tanaka, S., Bluestone, J.A., Takayanagi, H.
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nature Medicine. 20(1), 62-8 (2014) [Pubmed]

Oh-Hora, M., Komatsu, N., Pishyareh, M., Feske, S., Hori, S., Taniguchi, M., Rao, A., Takayanagi, H.
Agonist-Selected T Cell Development Requires Strong T Cell Receptor Signaling and Store-Operated Calcium Entry. Immunity. 38(5), 881-895 (2013) [Pubmed]

Komatsu, N., Takayanagi, H.
Autoimmune arthritis: the interface between the immune system and joints. Adv Immunol. 115, 45-71 (2012) [Pubmed]

Komatsu, N., Takayanagi, H.
Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints. Front Immunol. 3, 77 (2012) [Pubmed]

Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R.H., Takayanagi, H.
Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nature Medicine. 17(11), 1473-80, (2011) [Pubmed]

Tsuji, M.*, Komatsu, N.*, Kawamoto, S.*, Suzuki, K., Kanagawa, O., Honjo, T., Hori, S., Fagarasan, S.
Preferential generation of follicular B helper T (TFH) cells from Foxp3+T cells in gut Peyer’s patches. Science. 323(5920), 1488-92. (2009) *equally contributed [Pubmed]

Komatsu, N., Mariotti-Ferrandiz, M.E., Wang, Y., Malissen, B., Waldmann, H., Hori, S.
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A. 106(6), 1903-8 (2009) [Pubmed]

Komatsu, N., Waki, M., Sue, M., Tokuda, C., Kasaoka, T., Nakajima, M., Higashi, N., Irimura, T.
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies. J Immunol Methods. 331(1-2), 82-93 (2008) [Pubmed]

Komatsu, N., Hori, S.
Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc Natl Acad Sci U S A. 104(21), 8959-64 (2007) [Pubmed]

Sato, K., Komatsu, N., Higashi, N., Imai, Y., Irimura, T.
Granulation tissue formation by nonspecific inflammatory agent occurs independently of macrophage galactose-type C-type lectin-1. Clin Immunol. 115(1), 47-50 (2005) [Pubmed]