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新田 剛
Takeshi Nitta, Ph.D.


東京大学大学院医学系研究科 免疫学 准教授
E-mail address: nit-im[@]m.u-tokyo.ac.jp



原著論文・総説・著書(英文)

Muro R, Nitta T*, Nakano K, Okamura T, Takayanagi H*, Suzuki H*. γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program. (*corresponding authors) J Clin Invest.2017 doi: 10.1172/JCI95837 [Epub ahead of print]

Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, Nakashima T, Takayanagi H. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun. 493(1):437-443.(2017) [PubMed]

Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol. 2(12).(2017)

Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol.18(6):675-682. (2017) 表紙(June 2017, Vol.18 No.6)に採用[PubMed]

Tsukasaki M, Hamada K, Okamoto K Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H. LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res. 32(3):434-439. (2017) [PubMed]

Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H. IL-17-producing γδ T cells enhance bone regeneration. J Nat Commun. 7:10928.(2016)[PubMed]

Nitta T, Suzuki H. Thymic stromal cell subsets for T cell development. Cell Mol Life Sci. 73, 1021-1037. (2016)[PubMed]

Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, Kodama T, Takayanagi H. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Cell. 163(4): 975-87 (2015)[PubMed]

Muro R, Nitta T, Okada T, Ideta H, Tsubata T, Suzuki H. The Ras GTPase-activating protein Rasal3 supports survival of naïve T cells. PLoS One. 10, e0119898 (2015)[PubMed]

Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells. EMBO Rep. 16, 638-653 (2015)[PubMed]

Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H. Differential function of Themis CABIT domains during T cell development. PLoS One, 9, e89115, 2014. [PubMed]

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
 Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.
 J Immunol, 192, 630-640, 2014. [PubMed]

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
 Traf3 enforces the requirement for T cell crosstalk in thymic medullary epithelial development.
 Proc Natl Acad Sci USA, 110 21107-21112, 2013. [PubMed]

Nitta T, Ohigashi, I., Takahama, Y. The development of T lymphocytes in fetal thymus organ culture. Methods Mol Biol, 946, 85-102, 2013. [PubMed]

*Nakagawa, Y. *Ohigashi, I., *Nitta, T., *Sakata, M., Tanaka, K., Murata, S., Kanagawa, O., Takahama, Y. Thymic nurse cells provide microenvironment for secondary TCRa rearrangement in cortical thymocytes. Proc Natl Acad Sci USA, 109, 20572-20577, 2012. (*, equal contribution) [PubMed]

Zuklys, S., Mayer, C.E., Zhanybekova, S., Stefanski, H.E., Nusspaumer, G., Gill, J., Barthlott, T., Chappaz, S., Nitta, T., Dooley, J., Nogales-Cadenas, R., Takahama, Y., Finke, D., Liston, A., Blazar, B.R., Pascual-Montano, A., Holländer, G.A. MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection. J Immunol, 189, 3894-3904, 2012. [PubMed]

Roberts, N.A., White, A.J., Jenkinson, W.E., Turchinovich, G., Nakamura, K., Withers, D.R., McConnell, F.M., Desanti, G.E., Benezech, C., Parnell, S.M., Cunningham, A.F., Paolino, M., Penninger, J.M., Simon, A.K., Nitta, T., Ohigashi, I., Takahama, Y., Caamano, J.H., Hayday, A.C., Lane, P.J., Jenkinson, E.J., Anderson, G. Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium. Immunity, 36, 427-437, 2012.[PubMed]

Ishimaru, N., Yamada, A., Nitta, T., Arakaki, R., Lipp, M., Takahama, Y., Hayashi Y. CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. Am J Pathol, 180:199-208, 2012.[PubMed]

*Ohigashi, I., *Nitta, T., Lkhagvasuren, E., Yasuda, H., Takahama, Y.
 Effects of RANKL on the thymic medulla.
Eur J Immunol, 41, 1822-1827, 2011. (*, equal contribution)[PubMed]

Mat Ripen, A., Nitta, T., Murata, S., Tanaka, K., Takahama, Y. Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit b5t. Eur J Immunol, 41, 1278-1287, 2011.[PubMed]

Lei, Y., Mat Ripen, A., Ishimaru, N., Ohigashi, I., Nagasawa, T., Jeker, L.T., Bösl, M.R., Holländer, G.A., Hayashi, Y., de Waal Malefyt, R., Nitta, T., Takahama, Y. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med, 208, 383-394, 2011. [PubMed]

Nitta, T., Ohigashi, I., Nakagawa, Y., Takahama, Y. Cytokine crosstalk for thymic medulla formation. Curr Opin Immunol, 23, 190-197, 2011.[PubMed]

White, A.J., Nakamura, K., Jenkinson, W.E., Saini, M., Sinclair, C., Seddon, B., Narendran, P., Pfeffer, K., Nitta, T., Takahama, Y., Caamano, J.H., Lane, P.J.L., Jenkinson, E.J., Anderson, G. Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J Immunol, 185, 4769-4776, 2010. [PubMed]

Hidaka, K., Nitta, T., Sugawa, R., Schwartz, R.J., Amagai, T., Nitta, S., Takahama, Y., Morisaki, T. Differentiation of pharyngeal endoderm from mouse embryonic stem cell. Stem Cells Dev, 19, 1735-1743, 2010. [PubMed]

Takahama, Y., Nitta, T., Mat Ripen, A., Nitta, S., Murata, S., Tanaka, K. Role of thymic-cortex-specific self-peptides in positive selection of T cells. Semin Immunol, 22, 287-293, 2010. [PubMed]

Nitta, T., Murata, S., Sasaki, K., Fujii, H., Mat Ripen, A., Ishimaru, N., Koyasu, S., Tanaka, K., Takahama, Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity, 32, 29-40, 2010. [PubMed]

Tosa, N., Iwai, A., Tanaka, T., Kumagai, T., Nitta, T., Chiba, S., Maeda, M., Takahama, Y., Uede, T., Miyazaki, T. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Biochem Biophys Res Commun, 395, 356-360, 2010. [PubMed]

Ishimaru, N., Nitta, T., Arakaki, R., Yamada, A., Lipp, M., Takahama, Y. Hayashi, Y. In situ Patrolling of Regulatory T cells is Essential for Protecting Autoimmune Exocrinopathy. PLoS One, 5, e8588, 2010.[PubMed]

Nitta, T., Nitta, S., Lei, Y., Lipp, M., Takahama, Y. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci USA, 106, 17129-17133, 2009. [PubMed]

Nitta, T., Takahama, Y. Towards understanding how immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments. Systems Biology: Challenge of Complexity. eds. Nakanishi S, Kageyama R, Watanabe D. Springer, Tokyo, 71-82, 2009. [Link]

Nitta, T., Murata, S., Ueno, T., Tanaka, K., and Takahama, Y. Thymic microenvironments for T-cell repertoire formation. Adv Immunol, 99, 59-94, 2008. [PubMed]

*Hikosaka, Y., *Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J.M., Takayanagi, H., Yokota, Y., Yamada, H., Yoshikai, Y., Inoue, J., Akiyama, T., Takahama, Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity, 29, 438-450, 2008. (*, equal contribution) [PubMed]

Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J.M., Matsumoto, M., Nitta, T., Takahama, Y., Inoue, J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity, 29, 423-437, 2008. [PubMed]

Irla, M., Hugues, S., Gill, J., Nitta, T., Hikosaka, Y., Williams, I.R., Hubert, F.X., Scott, H.S., Takahama, Y., Hollander, G.A., Reith, W. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity, 29, 451-463, 2008. [PubMed]

Nitta, T., Takahama, Y. The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol, 28, 58-65, 2007. [PubMed]

Nitta, T., Nasreen, M., Seike, T., Goji, A., Ohigashi, I., Miyazaki, T., Ohta, T., Kanno, M., Takahama, Y. IAN family critically regulates survival and development of T lymphocytes. PLoS Biology, 4(4):e103, 2006. [PubMed]

Ueno, T., Liu, C., Nitta, T., Takahama, Y. Development of T-lymphocytes in mouse fetal thymus organ culture. Methods Mol Biol, 290, 117-133, 2005. [PubMed]

Liu C, Ueno T, Kuse S, Saito F, Nitta, T., Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood, 105, 31-39, 2005. [PubMed]

Nitta, T., Chiba A., Yamamoto N., Yamaoka S. Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma. Cell Signal, 16:1071-1081, 2004. [PubMed]

Nitta, T., Chiba, A., Yamashita, A., Rowe, M., Israel, A., Reth, M., Yamamoto, N. Yamaoka, S. NF-kB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. Cell Signal, 15, 423-433, 2003. [PubMed]

Nitta, T., Igarashi, K. Yamamoto, N. Polyamine depletion induces apoptosis through mitochondria-mediated pathway. Exp Cell Res, 276, 120-128, 2002. [PubMed]

Nitta, T., Igarashi, K., Yamashita, A., Yamamoto, M. Yamamoto, N. Involvement of polyamines in B cell receptor-mediated apoptosis: spermine functions as a negative modulator. Exp Cell Res, 265, 174-183, 2001. [PubMed]

Nitta, T., Nagamitsu, H., Murata, M., Izu, H. Yamada, M. Function of the sigma(E) regulon in dead-cell lysis in stationary-phase Escherichia coli. J Bacteriol, 182, 5231-5237, 2000. [PubMed]

Yamada, M., Talukder, A.A., Nitta, T. Characterization of the ssnA gene, which is involved in the decline of cell viability at the beginning of stationary phase in Escherichia coli. J Bacteriol, 181, 1838-1846, 1999. [PubMed]

Yamada, M., Izu H., Nitta, T., Kurihara, K., Sakurai, T. High-temperature, nonradioactive primer extension assay for determination of a transcription-initiation site. Biotechniques, 25, 72-74, 1998. [PubMed]

和文(総説)

Matsui, N., Nitta, T., Takahama, Y. Development of the thymus and immune system. Brain Nerve, 63, 679-684, 2011.[PubMed]

新田 剛、高浜洋介「胸腺プロテアソームによるCD8+ T細胞のレパトア形成」医学のあゆみ 234(12): 1129-1130, 2010.

新田 剛、高浜洋介「CD8+ T細胞のレパートリー形成と胸腺プロテアソーム」臨床免疫・アレルギー科 54(3): 392-398, 2010.

新田 剛、高浜洋介「胸腺の髄質形成」感染・炎症・免疫 39(2): 26-35, 2009.

新田 剛、上野智雄、高浜洋介「胸腺髄質微小環境を形成するサイトカインとケモカイン」実験医学 27: 1764-1769, 2009.

新田 剛、高浜洋介「胸腺クロストークシグナルと髄質形成」Annual Review 2008 免疫:162-168, 2007.

新田 剛、高浜洋介「T系列細胞の胸腺内移動とケモカイン・接着分子」臨床免疫・アレルギー科 46:474-478, 2006.

新田 剛、高浜洋介「T細胞レパトア形成と胸腺微小環境」実験医学増刊・免疫研究最前線2007 24:35-41, 2006.

新田 剛、高浜洋介「中枢性トレランスと自己免疫疾患」日本臨床免疫学会会誌 29: 8-15, 2006.

新田 剛、高浜洋介「中枢性免疫寛容の分子機序−自己寛容の成立に関する分子機序」分子細胞治療 2: 3-7, 2003.

新田 剛、高浜洋介「T細胞選択を制御する分子シグナル」臨床免疫 39: 201-208, 2003.

受賞歴

平成20年度 徳島大学若手研究者学長表彰(2008年12月)

平成21年度 岡奨学賞(徳島大学医学部)(2010年3月)

第5回 日本免疫学会研究奨励賞(2010年12月)

平成22年度 康楽賞(徳島大学)(2011年1月)

アステラス病態代謝研究会 最優秀理事長賞(2011年11月)

社会活動

「免疫ふしぎ未来2013」実行委員(平成25年8月11日開催)。

「免疫ふしぎ未来2014」実行委員(平成26年8月10日開催)。

「免疫ふしぎ未来」Facebook管理者(https://www.facebook.com/MennekiFushigi)。

徳島大学疾患ゲノム研究センター遺伝子実験施設「高校生のための遺伝子組換え実験講習会」講習指導員(平成17〜22年)。

「科学・技術ミーティング in 高松」(平成22年8月29日)