呉羽 拓
Taku Kureha, Ph.D.
東京大学大学院医学系研究科 免疫学講座 講師
E-mail address: kure-im[@]m.u-tokyo.ac.jp
原著論文・総説・著書（英文)
Meng Xu*, Taku Ito-Kureha*, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer. (*equal contributions) The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nature communications.11;15(1):2194. (2024) [link]
Cristina Leoni#, Marian Bataclan#, Taku Ito-Kureha, Vigo Heissmeyer & Silvia Monticelli. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nature communications.29;14(1):3862. (2023) [link]
Taku Ito-Kureha*, Vigo Heissmeyer* (*Co-corresponding author) Critical functions of N6-adenosine methylation of mRNAs in T cells. BBA - Mol. Cell Res.(2022) [link]
Taku Ito-Kureha, Cristina Leoni, Kayla Borland, Giulia Cantini, Marian Bataclan, Rebecca N. Metzger, Gregor Ammann, Anne B. Krug, Annalisa Marsico, Stefanie Kellner, Stefan Canzar, Stefan Feske, Silvia Monticelli, Julian König, Vigo Heissmeyer. The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Nature Immunology.25; 23, 1208-1221. (2022) [link][Press release]
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher & Vigo Heissmeyer. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nature communications.01;12:5208. (2021) [link]
Taku Ito-Kureha, Miyao Takahisa, Saori Nishijima, Toru Suzuki, Shin-ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro, Hiroki Ishikawa, Hidenori Ichijo, Taishin Akiyama and Tadashi Yamamoto. The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nature communications.2;11(1):6169. (2020) [link]
Franziska Weichmann, Robert Hett, Aloys Schepers, Taku Ito-Kureha, Andrew Flatley, Kaouthar Slama, Florian Hastert, Nick Angstmann, Cristina M Cardoso, Julian König, Stefan Huettelmaier, Christoph Dieterich, Stefan Canzar, Mark Helm, Vigo Heissmeyer, Regina Feederle and Gunter Meister. Validation strategies for antibodies targeting modified ribonucleotides. RNA.26(10):1489-1506. (2020) [link]
Dina Mostafa, Akinori Takahashi, Akiko Yanagiya, Tomokazu Yamaguchi, Takaya Abe, Taku Kureha, Keiji Kuba, Yumi Kanegae, Yasuhide Furuta, Tadashi Yamamoto & Toru Suzuki. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol.10:1-14. (2020) [link]
Kuniaki Nerome, Taku Ito-Kureha, Tiziana Paganini, Takao Fukuda, Yasuhiro Igarashi, Hiroto Ashitomi, Shinya Ikematsu, Tadashi Yamamoto. Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands. Am J Cancer Res. 10(2): 581-594. (2020)
Borland K, Diesend J, Ito-Kureha T, Heissmeyer V, Hammann C, Buck AH, Michalakis S, Kellner S. Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis. Genes.10(1): 26. (2019) [link]
Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T., Seiki, M. and Inoue, J. Tropomodulin1 expression driven by NF-kB enhances breast cancer growth. Cancer Research.1;75(1):62-72. (2015) [link]
Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N and Inoue J. NF-kB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. Nature communications.4: 2299. (2013) [link]
Yamamoto M, Ito T, Shimizu T, Ishida T, Semba K, Watanabe S, Yamaguchi N, Inoue J. Epigenetic alteration of the NF-kB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. Cancer Science.101(11): 2391-7. (2010) [link]
Ami Watanabe, Seiji Maruo, Taku Ito, Miho Ito, Koichi Ricardo Katsumura, and Kenzo Takada. Epstein-Barr Virus-Encoded Bcl-2 Homologue Functions as a Survival Factor in Wp-Restricted Burkitt Lymphoma Cell Line P3HR-1. JOURNAL OF VIROLOGYVol. 84, No. 6, p. 2893–2901. (2010) [link]
Maruo S, Wu Y, Ito T, Kanda T, Kieff ED, Takada K. Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth. Proc Natl Acad Sci U S A.106 (11), 4419-4424. (2009) [link]
Noritaka Yamaguchi, Taku Ito, Sakura Azuma, Emi Ito, Reiko Honma, Yuka Yanagisawa, Akira Nishikawa, Mika Kawamura, Jun-ichi Imai, Shinya Watanabe, Kentaro Semba, and Jun-ichiro Inoue. Constitutive activation of NF-kB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines. Cancer Science.100(9): 1668-74. (2009) [link]
総説/著書（和文）
呉羽 拓：T 細胞受容体シグナルを制御するmRNA修飾の仕組み
月刊「臨床免疫・アレルギー科」第 80 巻第 1 号（2023年7月発行）、2023
