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研究業績

総説・書籍(英文)

総説
  • Takaba H, Takayanagi H. The Mechanisms of T Cell Selection in the Thymus. Trends Immunol. pii: S1471-4906(17)30148-5. (2017) [Epub ahead of print]
  • Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, Sawa S, Nitta T, Takayanagi H. Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.Physiol Rev. 97(4):1295-1349. (2017) [PubMed]
  • Takaba H, Takayanagi H. The Mechanism of T Cell Selection in the Thymus. Trends Immunol. in press (2017)
  • Ono T, Takayanagi H. Osteoimmunology in Bone Fracture Healing. Curr Osteoporos Rep . 15(4):367-375 (2017) [PubMed]
  • Komatsu N, Takayanagi H. Regulatory T cells in Arthritis. Prog Mol Biol Transl Sci. . 136:207-15(2015) [PubMed]
  • Takayanagi H. SnapShot: Osteoimmunology. Cell Metab. 21(3):502-502.e1. (2015) [PubMed]
  • Takayanagi H. Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption. Nat Rev Rheumatol. 11(2):74-6 (2015) [PubMed]
  • Komatsu N, Takayanagi H. Arthritogenic T cells in autoimmune arthritis. Int J Biochem Cell Biol. 58:92-6 (2015) [PubMed]
  • Guerrini MM, Takayanagi H. The immune system, bone and RANKL. Arch Biochem Biophys. 561:1118-123 (2014) [PubMed]
  • Danks L, Takayanagi H. Immunology and bone. J Biochem. 154(1):29-39 (2013) [PubMed]
  • Takayanagi H. New developments in osteoimmunology. Nat Rev Rheumatol. 8(11):684-9 (2012) [PubMed]
  • O'Brien CA, Nakashima T, Takayanagi H. Osteocyte control of osteoclastogenesis. Bone. 54(2):258-63 (2012) [PubMed]
  • Nakashima T, Hayashi M, Takayanagi H. New insights into osteoclastogenic signaling mechanisms. Trends Endocrinol Metab. 23(11):582-90 (2012) [PubMed]
  • Komatsu N, Takayanagi H. Autoimmune arthritis: the interface between the immune system and joints. Adv. Immunol. 115:45-71 (2012) [PubMed]
  • Komatsu N, Takayanagi H. Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints. Front Immunol. 3:77 (2012) [PubMed]
  • Negishi-Koga T, Takayanagi H. Bone cell communication factors and Semaphorins. Bonekey Rep. 1:183 (2012) [PubMed]
  • Nakashima T, Takayanagi H. New regulation mechanisms of osteoclast differentiation. Ann N Y Acad Sci. 1240:13-8 (2011) [PubMed]
  • Takayanagi H. Introduction to the special issue "The interaction among bone, immunology and vascular biology". Inflammation and Regeneration. 31(5):399-403 (2011) [PDF]
  • Nakashima T, Takayanagi H. Osteoimmunology: the effect of inflammation on bone. Inflammation and Regeneration. 31(5):404-12 (2011) [PDF]
  • Okamoto K, Takayanagi H. Potential molecular targets for suppressing Th17 development. Inflammation and Regeneration. 31(4):354-360 (2011)
  • Okamoto K, Takayanagi H. Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther. 13(3):219 (2011) [PubMed]
  • Okamoto K, Takayanagi H. Osteoclasts in arthritis and Th17 cell development. Int Immunopharmacol. 11:543-548 (2011) [PubMed]
  • Takayanagi H. New immune connections in osteoclast formation. Ann N Y Acad Sci. 1192(1):117-23 (2010)
  • Takayanagi H. The unexpected link between osteoclasts and the immune system. Adv Exp Med Biol. 658:61-8 (2010) [PubMed]
  • Takayanagi H. Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol. 5(12):667-76 (2009) [PubMed]
  • Gober HJ, Takayanagi H. The interactions and shared mechanisms of T cells and osteoclasts. Inflammation and Regeneration. 29 (4):239-48 (2009)
  • Negishi-Koga T, Takayanagi H. Ca2+ -NFATc1 signaling is an essential axis of osteoclast differentiation. Immunological Reviews. 231(1):241-56 (2009) [PubMed]
  • Negishi-Koga T, Takayanagi H. Mysteries in Ca2+ signaling during osteoclast differentiation. IBMS BoneKEy (2009) 6:301-306 (2009) [link]
  • Nakashima T, Takayanagi H. Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol. 29(5):555-67 (2009) [PubMed]
  • Nakashima T, Takayanagi H. Osteoclasts and the immune and system. J Bone Miner Metab. 27(5):519-29 (2009) [PubMed]
  • Nakashima T, Takayanagi H. The dynamic interplay between osteoclasts and the immune system. Arch Biochem and Biophys. 473(2):166-71 (2008) [PubMed]
  • Takayanagi H. The role of NFAT in osteoclast formation. Ann NY Acad Sci. 1116:227-237 (2007) [PubMed]
  • Takayanagi H. Novel signaling pathways and therapeutic targets in osteoclasts. Adv Exp Med Biol. 602:93-6 (2007) [PubMed]
  • Takayanagi H. Interaction between the immune system and bone metabolism: anemerging field of osteoimmunology. Proc Jpn Acad. Ser B 83:136-143 (2007)
  • Shinohara M, Takayanagi H. Novel osteoclast signaling mechanisms. Curr Osteoporos Rep. 5(2):67-72 (2007) [PubMed]
  • Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the bone and immune systems. Nat Rev Immunol. 7(4):292-304 (2007) [PubMed]
  • Asagiri M,, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 40(2):251-64 (2007) [PubMed]
  • Sato K, Takayanagi H. Osteoclasts, rheumatoid arthritis, and osteoimmunology. Curr Opin Rheumatol. 18(4):419-26 (2006) [PubMed]
  • Takayanagi H. Amazing multifunctionality of calcineurin and NFAT signaling in bone homestasis. BoneKEy-osteovision (2006) 3:28-31 (2006) [Link]
  • Takayanagi H, Sato K, Takaoka A, Taniguchi T, Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev. 208:181-93. (2005) [PubMed]
  • Takayanagi H. Osteoimmunological insight into bone damage in rheumatoid arthritis. Mod Rheumatol. 15(4):225-31 (2005) [PubMed]
  • Takayanagi H. Inflammatory bone destruction and osteoimmunology. J Periodontal Res. 40(4):287-93 (2005) [PubMed]
  • Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med. 83(3):170-9 (2005) [PubMed]
  • Takayanagi H, Kim S, Koga T, Taniguchi T. Stat1-mediated cytoplasmic attenuation in osteoimmunology. J Cell Biochem. 94(2):232-40 (2005) [PubMed]
  • Takayanagi H. All Interferons are Not Equal: Specific Mechanisms of Interfering with Osteoclastogenesis. BoneKEy-Osteovision (2005) 2:24-28 (2005) [link]
  • Takayanagi H, Kim S, Taniguchi T. Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res. 4 Suppl 3:S227-32 (2002) [PubMed]
  • Takayanagi H. How does the immune system break and protect bone? Science. on line (2002) [Link]
書籍
  • Shinohara M, Takayanagi H. Transcription Factor Regulatory Networks: Methods and Plotocols, Chapter14: Analysis of NFATc1-Centered Transcription Factor Regulatory Networks in Osteoclast Formation. Methods Mol Biol. 1164:171-6 Springer New York (2014)
  • Nakashima T, Takayanagi H. RANK and RANKL. Encyclopedia of Signaling Molecules. Springer. 1581-1589 (2012)
  • Okamoto K, and Takayanagi H. Arthritis: Pathophysiology, Prevention, and Therapeutics. Overview and Pathophysiology Chapter 5: Osteoclasts and interleukin-17-producing helper T cells in rheumatoid arthritis. 75-89 CRC Press (2011)
  • Lorenzo J, Choi Y, Horowitz M, Takayanagi H.(Editors), Osteoimmunology: Interactions of the Immune and Skeletal Systems. Academic Press (2010)
  • Takayanagi H. The Skeletal System, Chapter 9: Cytokine and growth factor regulation of osteoclastogenesis. 263-70 Cold Spring Harbor Laboratory Press (2009)